A NEW BRD TREATMENT OPTION - WITH FEVER CONTROL

Some treatments for BRD have been missing something: an ingredient to control the fever that can accompany infection.

Beef producers understand the threat of bovine respiratory disease (BRD) and the importance of treating it as soon as possible to minimize symptoms and their long-term effects. 

Fortunately, there are highly effective antibiotics available that treat BRD. Of those, Draxxin® (tulathromycin injection) Injectable Solution has been demonstrated more successful at treating BRD than competitive antimicrobials.1 In fact, two recent meta-analysis studies found producers could potentially have significantly fewer repeat treatment courses for BRD using Draxxin as the first-line choice for treatment of BRD compared with alternative antibiotic treatments.2,3

But — until now — most of those treatments did not address a major symptom of BRD: fever. 

“With BRD, there can be an underlying fever, which can progress quickly and lead to appetite loss,” said Shawn Blood, DVM, managing veterinarian, beef strategic technical services, Zoetis. “Treating the fever can help the animal feel better.4,* Think about when you have the flu — when your fever breaks, you feel better.”

A new treatment option to fill the gap

Now there’s Draxxin® KP (tulathromycin and ketoprofen injection) Injectable Solution. It starts with the effectiveness of Draxxin and adds ketoprofen, a fast-acting nonsteroidal anti-inflammatory drug (NSAID), to control fever — and treat BRD — all in one shot. 

“Using an NSAID together with an antibiotic can support animal well-being4,* and reduce the fever that typically comes with BRD, compared with using an antibiotic treatment alone,” Blood said.

A multisite study demonstrated the effectiveness of ketoprofen for the control of fever associated with BRD in beef cattle: a statistically significant greater proportion of animals saw a 2° F or greater reduction in rectal temperature in the group receiving Draxxin KP compared with the control group from one hour up to 24 hours after treatment.5

Draxxin KP starts working fast against fever and the four major bacterial pathogens associated with BRD.6 “It’s long-lasting too: the antibiotic continues at therapeutic levels for up to 14 days; it’s one of the longest-acting antibiotics on the market,” Blood said.6 And it has a short meat withdrawal of just 18 days.

Additional benefits

There are animal welfare benefits to choosing Draxxin KP too. Because it supports a fast and effective recovery from BRD, it can help improve well-being.4 In a study, animals treated with Draxxin KP showed numerically improved respiratory and attitude scores compared with animals treated with Draxxin alone and saline.4,* 

A single successful treatment of new Draxxin KP can mean fewer injections. “That can help reduce labor time, help improve return on investment and, ultimately, help support responsible use of antibiotics,” Blood said.2,3 “A highly efficacious single treatment clears the infection and may reduce the need for additional treatment. That allows veterinarians and producers to be more responsible stewards of antibiotics.”

When cattle get sick, fast and successful treatment is crucial — you want to know you’re doing all you can for them. “Draxxin KP is demonstrated to treat BRD and control fever effectively, which means cattle are likely to make a fast recovery from BRD,” Blood said.4-6 “It’s a step forward in BRD treatment.”

IMPORTANT SAFETY INFORMATION FOR DRAXXIN KP: Draxxin KP has a pre-slaughter withdrawal time of 18 days in cattle. Not for use in female dairy cattle 1 year of age or older, including dry dairy cows. Not for use in beef calves less than 2 months of age, dairy calves, and veal calves. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in animals previously found to be hypersensitive to tulathromycin and ketoprofen.  See full Prescribing Information.

IMPORTANT SAFETY INFORMATION FOR DRAXXIN: Draxxin has a pre-slaughter withdrawal time of 18 days in cattle. Do not use in female dairy cattle 20 months of age or older. Do not use in animals known to be hypersensitive to the product. See full Prescribing Information.

IMPORTANT SAFETY INFORMATION FOR KETOFEN: Ketofen has a pre-slaughter withdrawal time of within 48 hours following last treatment. Not for use in female dairy cattle 1 year of age or older, including dry dairy cows. Not for use in beef calves less than 2 months of age, dairy calves, and veal calves. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in animals showing hypersensitivity to ketoprofen. The effects of Ketofen on bovine reproductive performance, pregnancy, lactation, or on animals of reproductive age intended for breeding has not been studied. See full Prescribing Information.

References 

*Animals treated with Draxxin KP showed numerically improved attitude and respiratory scores compared with animals treated with saline and Draxxin post-treatment.

1 Data on file, Study Report Nos. 1133R-60-05-491, A131R-US-12-028, 2132T-60-01-050, 1133R-60-02-376, 2132T-60-01-063, 1133R-60-03-388 and 11RGDRA01, Zoetis Inc.
2 Poulsen Nautrup B, Van Vlaenderen I, Decker M, Cleale RM. Antimicrobial drug use for control and treatment of bovine respiratory disease in U.S. feedlot cattle: A meta-analysis. Bov Pract. 2017;51(1);1-13.
3 O’Connor AM, Yuan C, Cullen JN, Coetzee JF, da Silva N, Wang C. A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease — An update. Prev Vet Med. 2016;132:130-139.
4 Data on file, Study Report No. A131C-XC-17-528 and Report Amendment 01, Zoetis Inc.
5 Data on file, Study Report No. A131C-US-15-343, Zoetis Inc.
6 Data on file, Study Report No. A431N-US-16-418, Zoetis Inc.

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